Better take an advil

Macrophages just want to watch the whole body burn.
- From what I've read, anything over about 101F is doing more harm than good.
  
  That's 38C for anyone out of the US
  
  This does not appear to match the evidence anymore: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7717216/
  The body is generally unable to raise the core temperature to the point where it can cause permanent damage, unless the ambient temperature is high. That is, unless there is a pre-existing heart or other vital organ condition.
  In fact, fevers >=39C (102.2F) showed better outcomes in covid patients.

To me Macrophages are the single most interesting creatures(symbiotes?) in the human body. I've read so much about them yet know so little.
- Its their body, we are just the pilot.
  
  Haha, yeah, sounds about right! No neurons, yet so determined.
- Watch cells at work, you will thank me later
  
  I've had this Excel workbook open for an hour now and my boss is asking why I'm just staring at it. But thank you?

I only know ibuprofen as a pain killer, but good to know it can also reduce fever!
- It blocks inflammation of all sorts
- It was the key drug being deployed during the covid war. I survived tks to it. Saw god a few times.
  
  Reading this makes me think it was thorazine instead of ibuprofen.
  
  Interesting, as someone who takes Suboxone, I avoid Tylenol because of potential liver issues. I was told during the pandemic that ibuprofen caused things to be worse. It was a confusing time and a very scary time.
  It’s hard to know what info to trust these days.

Having a fever I can deal with, but I will immediately take some meds to not have a headache. Unfortunately, usually a fever comes with a headache.:(

Ibuprofen does not reduce a fever, it reduces inflammation. Tylenol would have made this meme work
Edit: I was wrong
- The first sentence on ibuprofens wikipedia page under "Medical uses":
  Ibuprofen is used primarily to treat fever
  Anti-inflammatories reduce fevers, are there even anti-inflammatories that don't have that effect to some extent?
  
  So I was about to correct you that Tylenol is actually acetaminophen; turns out paracetamol is just another name for the same chemical. TIL
  
  Paracetamol is not anti-inflammatory in any serious context, which is to say taking paracetamol to reduce actual inflammation (think gout or rheumatoid arthritis) is more or less useless. From the wikipedia article on paracetamol:
  Paracetamol inhibits prostaglandin synthesis by reducing the active form of COX-1 and COX-2 enzymes. This occurs only when the concentration of arachidonic acid and peroxides is low. Under these conditions, COX-2 is the predominant form of cyclooxygenase, which explains the apparent COX-2 selectivity of paracetamol. Under the conditions of inflammation, the concentration of peroxides is high, which counteracts the reducing effect of paracetamol. Accordingly, the anti-inflammatory action of paracetamol is slight.
  It is, however, an analgesic.
  
  I'll be damned, I was almost certain it wasn't an antipyretic, but it looks like I was wrong. Thanks for correcting me.
  You didn't need to use such condescending language though, there was no need to be rude.
- Take both at the same time. They're synergistic and will reduce pain, inflammation, and fever better than a higher dose of each by themselves
  
  Nevermind that Tylenol's effective ingredient is paracetamol, which is also "just" an anti-inflammatory.
- Big yikes
- Tylenol is a brand of acetaminophen, which is bad for your liver.
  
  I am bad for my liver.
  
  It's metabolized by your liver, so is fat. It has a safe and therapeutic dosage range.
  
  Can't ibuprofen also damage your liver?
  
  Aspirin is bad for your liver as well, especially for kids. It disrupts the electron transport chain in the Krebs cycle which leads to fatty acids not being converted and since they don't belong into the mitochondria, they are expunged into small deposits in the liver. It's called microvesicular steatosis, or more commonly called fat liver.
  
  Ibuprofen (or NSAIDs in general) is bad for the liver as well and worse for the kidneys.
  Edit: confused kidneys and liver.