New Vaccine Can Completely Reverse Autoimmune Diseases Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease

This article is garbage but I'm a molecular biologist and the publication they're talking about is really neat.

The "ELI5 to the point of maybe reducing out the truth" way to explain it is that the researchers can add "flags" to proteins associated with immune responses that make cells pick them up and examine them. This is shown to work for allergins (so say, add a flag to peanut protein and the cells can look at it more closely, go "oh nvm this is fine" and stop freaking out about peanuts) as well as autoimmune diseases (where cells mistake other cells from the same body as potential threats).

It's not nearly to a treatment stage, but tbh this is one of the more exciting approaches I've seen, and I do similar research and thus read a lot of papers like this.

There's a lot of evidence that we are entering a biological "golden age" and we will discover a ton of amazing things very soon. It's worrysome that we still have to deal with instability in other parts of life (climate change, wealth inequality, political polarization) that might slow down the process of turning these discoveries into actual treatments we can use to make lives better...

Still, don't doubt everything you read! A lot of cool stuff is coming, the trick is getting it past the red tape

I've been following cures like this for years. There are three candidates in phase 2 trials right now that appear to work, they're mostly figuring out the doses needed and there's a big question on how long they last. Hopefully permanent but we don't know for sure.

Diabetics have just been so beaten down by this whole thing. I was told the cure was 10 years away 40 years ago. Even if the technology described here works we could be another 15 years before we see it. Researchers said it could be here as soon as 5 years, which is true if unrealistically optimistic. I believe the cure is coming but I'm not holding my breath until I'm actually in front of a doctor about to receive the cure whatever it happens to be.

Our immune systems are both one of the most fascinating things about us and for those with autoimmune issues like myself, the most annoying. Always good to see articles like this and I'm glad this focused on the actual science.

I'd love to sign up for the trial if they ever test it for vitiligo. There are wayyy more serious autoimmune issues that can and should be tested first for those truly suffering. Mine is just "hey look at weird color boy".

My wife has MS. And even though we are of course far from being at a point where the disease will be cured, articles like this give hope.

There are a lot of smart people who are dealing with the topic. Hopefully they can get something solid done soon!

I will click on this headline when the link is to Nature or Scientific American or the Mayo Clinic. Thank you very much.

Unpopular opinion: Anyone who refused the COVID vaccine should be banned from getting this.

Well it wouldn't grow my colon back but I'll take what I can get!

It's tough to see promising treatments and cures for Type 1. There have been huge inroads for treatment but a cure always seems just around the corner. Here's to hope for all the Type 1's and thank you for all the people looking to find that cure.

The research is interesting, but I don't appreciate the bullshit clickbait headline.

I have MS, I'll go wild once I hear it's approved. Until then I'll save my energy.

Permanently Deleted

I get to find out if I have ulcerative colitis or Crohns in a few days. This gives me hope that even if I have one of them, I won't have to take meds for the rest of my life, or worse, have parts of me removed.

I just got slapped with an auto immune problem with my thyroid. It's inflamed and will never go back to normal. So far I only have a fat neck and I'm stable but at any moment I might develop hypothyroidism because of this. I can't wait for this to work.

Edit: having said that... the source of this post has been known for clickbait bullshit articles so maybe I shouldn't hold my breath :(

Finally i can stop shitting my pants

Yes but can we make a boatload of money off it?

My wife has Type 1 diabetes and I have UC.

This would be a god-send, but Im not gonna hold my breath. Good news is always a lie.

This is extremely promising. If this "reverse vaccine" is brought to market and holds up in effectiveness, it could usher in a new era of health, this could spell the end of autoimmune disorders, allergies, and other negative immune responses.

I wonder what the implications for transplant recipients are.

Yeah, sure 🙄

Let's not put the cart before the horse.

... But also I'd like to point out that celiac is an autoimmune disease, so for some people this may be a vaccine against gluten free bread.

"an inverse vaccine"

Oh good, at least they didn't choose a name that's gonna cause confusion.

TIL you can wait until you have the disease to take the vaccine. So if my kid gets polio, I'll give them the vaccine then, but I don't want to risk anything bad happening so I'll wait. I'm glad I did my research.

Notably they trialled first for coeliac autoimmune, but it'll be 2024 before phase 2 results are out for that. About 10 years back there was a similar vaccine which also passed phase 1 trials but failed at phase 2. Phase 1 is basically testing that the vaccine does no harm in small groups and it is phase 2 where they measure if it is actually efficacious and to what level. If it passes phase 2, then get your hopes up.

As someone with Celiac disease with a women who also is celiac, this gives so much hope of living a normal life again.

Please happen !

Hopeing there was stem cells used in the research for no particular reason.

Reverse means you get rash?

Thanks for the time saving summary

Great! Can they start working on hair tonic now? Sheesh.

This is really amazing if true. They should not call it a vaccine or else hardly anyone will get it...

Reverse Type 1 Diabetes

Didn't even read past that lie.

Lol ok, sure