New Vaccine Can Completely Reverse Autoimmune Diseases Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease

Is it possible that other person was just full of shit?

Here was an update posted on Sept 12th, 2023 from the company behind the trials regarding the MS trials:

Anokion has completed patient enrollment early in the second and final MAD cohort of its MoveS-it (Multiple Sclerosis Study of ANK-700 to Assess Safety and Immune Tolerance) clinical trial to evaluate ANK-700 for the treatment of patients with multiple sclerosis. MoveS-it is a randomized, double-blind, placebo-controlled Phase 1 study evaluating ANK-700 for the treatment of patients with relapsing remitting multiple sclerosis (RRMS). MS is a demyelinating disease of the CNS, in which the immune system attacks the myelin sheath in the brain and spinal cord. RRMS is the most common type of MS, characterized by recurring episodes of new or worsening symptoms. Anokion has designed ANK-700 to re-educate the immune system by inducing antigen-specific tolerance to myelin-based autoantigens to reduce neuroinflammation in the brain and spinal cord.

Safety data from both the SAD and MAD cohorts supports that ANK-700 is safe and well-tolerated at all dose levels tested through the dose escalation period. Further, preliminary biomarker data from the MAD cohorts displays trends in antigen-specific immune tolerance and evidence of bystander suppression to related myelin antigens, which is critical to treating complex autoimmune diseases like MS.

The study will continue with a 12-month safety follow-up expected to complete in the first half of 2024. Anokion anticipates reporting full results from its MoveS-it clinical trial in the second half of 2024.

• Source

This says that the single dose (SAD) phase 1 trial which began in 2020 was completed and they moved on to the second multiple ascending dose trial (MAD) for MS which completed enrollment and expect results in 2024. And that the preliminary data from the first MAD trial indicates therapeutic response.

And the press release talks about how they've moved on to a phase 2 trial for its use for celiacs (the initial trial use case). And then on Oct 12th they announced they will be presenting data from their phase 1 for celiacs at a conference.

A week after the announcement quoted above they released the news about their peer reviewed paper mentioning the early success in both (what likely inspired OP's article), saying:

We have now observed our approach play out in the clinic with early data from our lead programs in celiac disease and multiple sclerosis, KAN-101 and ANK-700, that demonstrated antigen-specific tolerance, bystander suppression, and an impact on disease-specific biomarkers.

None of this looks like a company that has a failing drug on their hands. And there's no indication of the MS trial being ended early - the only thing that happened early was completing enrollment early.

Being too ready to give up on hope is its own kind of insanity.

Well damn, I got MS too but caught it fairly early. I'm hoping for a major breakthrough before it gets really bad.

I came for the Orange reference, but was not disappointed by Red.

So, if I understand this right, a more accurate title would be "Research into vaccines against autoimmune diseases continues, new data indicate that a change of focus might be needed"

have Crohn's. fingers crossed 🤞🏽

Here's the article that should have been posted, except of course that it's a few months old and nothing new has been reported on it yet that I know of. https://pme.uchicago.edu/news/inverse-vaccine-shows-potential-treat-multiple-sclerosis-and-other-autoimmune-diseases

like the good ol r/science

this place is going doooown

I see it in google news all the time. spammy but I don't see their ads. they gave references near the end.

What's bad is that it's a good article. It covers things very well

okay then

Article from September. First I'm hearing of it...

I wonder if it also applies to ulcerative colitis...

This still wont cure diabetes, but it will prevent it from developing or advancing if you catch it early enough.

This is the most boomer shit and it is so sad to see people still saying it

That's the way it reads, yes.

It would, if effective in human use, stop new damage, but not reverse existing damage.

Same but allergies.

Ehhh, maybe? If I'm reading the article right (and I haven't yet gone digging past the article to the source itself because that takes more time than I currently have), it's targeting t cells only. Rejection involves more than just t cells though.

It might be at least partially effective, I'm not trained in the field to be able to predict that much, just basing what I'm saying off of past reading and general information.

I'm not confident in this, though. It's pretty damn far beyond the level of actual training I've had. I can say confidently that the basic techniques they're talking about should be applicable to more than just autoimmune disorders, just not the degree of efficacy.

There's just so many more cells involved in something like hyperacute and acute rejection that it's likely to be something that would have to be more complicated than the already complicated technique they're working on.

I would say that, if this proves to work in actual humans safely and effectively, that the immune related cancers would be the more probable beneficiaries of the method.

See, most of the autoimmune stuff is a "false positive" the body at some point got fooled by some kind of external agent, that happened to match some part of the body. So, if you wipe out the "memory" of that false positive, the body stops attacking itself.

The cancers that are immune related should respond in a similar way. You'd still have the malignant cells, but it should stop new ones from going crazy, and the usual methods of killing off the existing malignant cells should effectively "cure" the person with drastically reduced chances of relapse.

But with transplants, there's no false positive. There actually are foreign cells in the body, being constantly exposed to immune cells. There's also usually more than one kind of cell, so the method they're using probably would need multiple efforts to work at all, and would likely need to be administered regularly. I'm fairly confident that the method could reduce severity of rejection, but that's still only fairly lol. But, (disclaimer again), the method should work in either a single or small number of treatments for autoimmune diseases.

I hope like hell this gets into human trials fast. I have a personal stake in it (hence all the reading lol) and what this thing can't do is undo the damage already done. The person being treated is still going to have whatever degree of disability the disease already caused, so the sooner people can start the treatment, the better off they are.

Most of the diseases explicitly listed as targets for this treatment are fucking brutal. Just one year with MS, as an example, can take someone from healthy and active to being half blind, or unable to walk unaided, or any number of other issues. MS already takes time to diagnose, so pretty much everyone that has it has some degree of disability by the time they start existing treatments. And the existing treatments, as incredible as they are, don't fully prevent new damage occurring. Nor do all of them work at full efficacy for everyone. You can end up having to try multiple treatments to find the right one for your immune system.

So, most MS patients have a serious amount of time before their disease even gets slowed. My wife, from diagnosis to first partially effective treatment, went almost a year, and lost so damn much from that time plus the effects from before diagnosis. You're talking someone that was modeling and a jogger being unable to walk down a hallway until over a year of physical therapy, and still can't handle long walks.

And she didn't even lose as much as some people do. She also deals with what's called relapsing/remitting MS (RRMS) which takes breaks between attacks. People with primary progressive MS (PPMS) can lose function faster and more severely. It's a fucking terrifying disease.

This is starting to go very long and tangential, so I'll stop after this bit.

I hope like hell it will work for not only the listed diseases, but rejection too. Gods, the lives it could make better if it can do all of that would change the world, along with the individual lives. It would be the scientific equivalent of a miracle cure.

I was under the impression that we were 5G access points with the covid vaccine?

Was I lied to? I thought I was doing a service to the fellow terminally online.