I have an all AMD system made of a Ryzen 5800 OEM, 48GB of memory and a 6900 XT. I've been using Linux almost exclusively for more than a few months and thankfully AMD hardware runs better on Linux that it did for me on Windows. Though I may add an nVidia GPU to the mix for VFIO fun for a no-compromises setup if I need something from Windows.

I also have a homelab machine with a 13900K ES and 32GB of memory. A 13900K is overkill but it has good single core performance for a gaming server and running docker services at the same time.

WINE doesn't work for everything. I've heard Adobe products are hit and miss and I have yet to get Office to work.