If you were a video game boss, what's the most likely or most fitting way the protagonist may beat you?

Blow some cannabis smoke in my face and point me in the direction of a comfortable chair. Now it’s a chill hangout session, not a boss fight. But you still win.
Completion reward: let’s share some pretzels
- Everybody wins

Ask me about something I'm above average knowledged about that I'm also interested in, and then you can disarm the bomb, save the pricess, destroy my entire species before I'm done oversharing the introductory part or even its preface.

- I love how this implies the protagonist just wants to die
  
  There was an edgy but very fun indie game a few years ago (maybe 5-6?) where one player played as a parent running around and childproofing the house while the other played as the baby trying to kill themselves. The game was surprisingly fun, and weirdly putting the logic you'd heard your entire life to keep children safe to die was always quiet funny, from getting forks to plugs to filling the bath etc.
  Taking inspiration to make a game in a psyche ward in a jail break / death is victory multiplayer game would probably make for a popular streaming game, although the topic is as horrible as the baby death game, perhaps worse because instead of being in the role of a silly unfortunate baby, you'd be in the role of somebody fully aware and acting with premeditation.

Bring as many npcs in the room as possible; then wait for the social anxiety to make me lock up

Ask nicely if they can scooch past. Id be mortified that I was in the way at all.

They'd probably handle me the same way as the fish boss in Earthworm Jim. Just one smack to the face and I'm done. That's all it takes.

Shares a granola bar full of peanuts and lies and tells me there's no peanuts in it. RIP me.

By making me chase after them for more than 30 seconds. Just go ahead, I'll catch up later.

I was driven mad by the unrelenting noises of society. The clamor, the insanity of humanity. The protagonistic figure decides a more peaceful option is adequate for my type of villainy and offers me quiet respite. A lovely cottage suitable for my hermit-like needs.
With this, I am at peace. I have a home. I have quiet. No quarrels with the world anymore
- What loot do you have to make it worthwhile for the protagonist?
  
  Hmmmmm, I might have a shiny rock or two. But I think the general public would be the providers of most appreciation awards due to not having me around anymore

Any way he choose. How would pick my as boss? That's a very bad move.
EDIT : God! What did I wrote?! I'm keeping this comment for posterity.

Show me the error in my ways so I can learn from it, or transform me from bad to good.

Exploiting my hubris.
I actually wrote out an outline for this back when I was making small videogames as a hobby. I never actually made the game, which was probably overly ambitious, which is fitting because it was a game about ambition and hubris with me as the villains (multiverse shenanigans) and a pair of scrappy teenage sleuths as the protagonists.

Probably shooting the chips from cutting a log with a chainsaw at my face. That’s gotten be at some point painful and extremely annoying.

I'm not an incompetent fighter or anything. I assume it wouldn't be a chance encounter, though, and I'd probably be prepared. In that case, well, they'd definitely have their work cut out for them. Prepare to dodge bullets, and engage in hand-to-hand combat with someone who can take a good beating before giving up.
I'm exhausted easily in my current state, however. Anything more than a short close quarters fight will likely do me in. That is, importantly, assuming I don't use 💫drugs💫.
- When you hit phase 2 of the fight and the boss pulls out a crack pipe

Intended method: three phase fight where the PC must break a magic shield before I get off a spell (DPS check). Breaking the shield releases a shockwave which either needs to be dodged or cancelled by an optional item (magic earmuffs). Failure to break the shield fails the fight, sends them to the room before (fuck you watch the whole cutscenes again)
Pacifist method: compliment me a couple of times and I won't know what to do with myself. I teleport away, leaving the key