You know this one's dated because I'm pretty sure by today's standards having only a C: drive is quite unusual. Hard to find statistics on it but I'd wager most people have at least 2 storage devices, especially an SSD / HDD combo is pretty popular.
This comic was ahead of its time. Back when it was written, optical disc drives were still common, so an external drive would be E: or higher. Now, though, it's actually realistic.
I have never met a female who seemed to be aware of what really is, at least other than "the part that stores stuff".
I'm not even trying to say I wanna date or be friends with one. That isn't a trait that's necessary at all. I know they exist, I've seen articles written by them and such. But I've never met one familiar with how a computer works at all.
I'd love to meet one just to prove to myself they're real. I want to believe... I mean I already know, but my brain just doesn't believe til it sees anymore.