People aren't familiar with most of their base material, and its still funny as hell. With the cultural familiarity to TOS it seems like it would be even more relatable? I dunno, but I would watch the hell out of it personally
RiffTrax (a MST3K spin-off created by Mike Nelson after the end of MST3Ks original run, and would eventually go on to include Kevin Murphy (Tom Servo) and Bill Corbett (Crow T. Robot)) actually riffs a bunch of the original series movies like Wrath of Khan.
Well folks, the crowdfunding for Season 14 has begun in earnest. If you want Joel, Jonah, Emily & the rest of the gang riffing stuff like The Original Series, get your manos on their crowdfunding!