Single-Dose Psilocybin for Major Depressive Disorder: Randomized Clinical Trial
Single-Dose Psilocybin for Major Depressive Disorder: Randomized Clinical Trial

jamanetwork.com
Single-Dose Psilocybin Treatment for Major Depressive Disorder

There is a discussion on Hacker News, but feel free to comment here as well.
I've had mild success with this but I was doing it very improperly without medical supervision, was definitely a trip that scared the shit out of me. Oddly enough though I've felt a lot better about an extreme case of nihilism that was definitely negatively impacting my well being. Definitely something interesting and worth more research.