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Theres a small indie game called Gods will be watching. Great pixel art, buut its main thing is crisis management, that happens with the player character, a hostage situation gone wrong, surviving on a desert planet behind enemy lines, and my favorite: making a cure for a deadly disease, while being caved in.
The virus couses paralysis, and in 72 hours shuts down your body systems. Not a fun way to go. All of your teammates are infected, which includes a doctor, a researcher, a robot engineer, a robot assistant, you and your friend who's a soldier, and his dog. The only way to make a cure in this deadline is abandoning all ethics and jumping to human trials.
First you synthetise the drug, the first of maybe on pure guesses, but each completed test narrows down the possible compounds needed for the cure. Each test has a chance of killing the "lab rat", you can try making it more stable, but it takes longer to make, and you don't have much time. Do you go for sale ones, or try to get the cure faster? Who would you sacrifice? Obviously not the doctor, he's needed for the cure. The researcher can help making drugs, so not her. The robot can't be tested on, but need repairs by the engineer, so not him. You can try on yourself, but if you die you fail, so you can't sacrifice yourself. Your friend? Or maybe the dog?
I don't know why I'm so engrossed with this game, is pretty old by now, and on youtube there's only a handful of playthroughs of it, but I really like the situations it puts the player in. Also the game is a bit punishing, but tells you before the game. There are no checkpoints in a chapter, which means you can lose 30+ progress by making a bad choise, out just having bad luck. But the mc has a... well not optimistic, but something similar vibe, like it doesn't matter how bad things are, you can always work in some way to your goal.