1y ago

A biotech company says it put dopamine-making cells into people’s brains

www.technologyreview.com A biotech company says it put dopamine-making cells into people’s brains

The experiment to treat Parkinson’s is a critical early test of stem cells’ potential to tackle serious disease.

A biotech company says it put dopamine-making cells into people’s brains::The experiment to treat Parkinson’s is a critical early test of stem cells’ potential to tackle serious disease.

Medicine @mander.xyz

Daryl76679 @lemmy.ml

1y ago

A biotech company says it put dopamine-making cells into people’s brains

www.technologyreview.com /2023/08/31/1078728/biotech-dopamine-making-cells-into-peoples-brains/

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This could help with more than just Parkinson's. ADHD, schizophrenia, depression, OCD, restless leg syndrome, chronic fatigue syndrome... these are all linked to abnormal dopamine levels.
I'm excited to see how this goes. The article makes it sound like their results have been just barely higher than what they might expect from a placebo, but hopefully that won't be the end of it.
- Yea. I have ADHD. Gimme dem dopamine cells. I'm tired of people talking shit because I take a prescribed stimulant.
  
  People say negative things about that? That's crazy, people are judgmental about stupid shit.
  
  Dude, I’ve gotten rejected from jobs because of it. Yes it’s illegal, no it’s often not worth suing if the government decides not to take the case
  
  Don't tell them next time.
  
  I’m not sure why this would ever come up in a job interview, it’s not your employer’s business.
  
  It wouldn't come up in an interview, unless it's a tiny business.
  Being ADHD myself, it wouldn't surprise me if the person above made it a topic of conversation themselves. Inability to shut ones mouth is something I am more than familiar with.
  
  It could also be a matter of them disclosing it to get accommodations.
  "By the way, I have ADHD, so might need a bit of help here and there" seems entirely reasonable for someone to say in an interview, but might also get them rejected.
  
  Oh it's totally reasonable to bring it up but I still wouldn't do it though.
  Rarely have I had a company be upfront about any issues they have so I am more than willing to reciprocate.
  
  Pre-employment drug screens test for amphetamines so it will come up on that screening if the company does them.
  
  I have never had a problem with that. If it's a prescription and it shows on a test, it's not any business of the prospective employer. When I am at the testing facility, I always disclose to them that I am taking amphetamines. I dunno if they have a box they need to check off for that, but I really don't care. Since my medications are legal, any disclosure of that testing data would fall directly into the category of HIPAA and not something your average company can handle.
  At least in the US, scheduled medication is tracked fairly hard. I suspect my name would come up if the testing facility checks for that kind of thing. (Just speculation: I have no idea how the system works on the backend.)
  More speculation: There may be specific markers in legal, scheduled medications. Is that a thing? If so, it might be a clue into legal or illegal use for the test.
  
  That's a good point. My understanding of how results are provided to employers was incorrect.
  
  You will come up positive on a pre employment drug test though correct?
  
  Depends on the drug. Not all of them do.
  
  I've literally had pharmacists "tut tut" me about being prescribed them, called an addict, questioned if I really need them, had them called legal meth. Like bitch, if my brain could get addicted to this shit, I wouldn't forget to take them!
  
  Ugh, yeh I hate judgemental pharmacists. I take a couple of controlled substances, but I've found a pharmacy nearby where they are super nice and happy to have my business. Now my whole family goes there for all our pharmacy needs, even if the shitty chain discount place might be a little cheaper.
  
  I have adhd and you know what's worse than taking stims every day? Not taking them! I sooo wish we had another solution
  
  Caffeine and Alcohol are a bit weird, since they don't have the stigma that other drugs do.
  If you say "Oh, I need a litre of coffee to function in the mornings", people would just laugh and agree, whereas if you said that you had to take your stimulant medication/dextroamphetamine to function/took the caffeine in pill form, people might judge you for it.
  You see it a bit with social media, where people say that ADHD is merely an excuse for laziness, and that medication does more harm than it helps, but will happily excuse people needing a coffee to start up in the morning.
- I personally would prefer more testing of psychedelics, like psilocybin. While that acts on the 5HT2A receptors causing more serotonin to be available (similar to SSRIs) it could potentially help with all of those conditions you listed as well. It absolutely helps my depression and anxiety and seems to have helped others.
  Oh. You can't patent a widely available mushroom. I grow and give them out for free.
  
  i hate giving anecdotal evidence, but i wasn't expecting it to be such a black and white change for me personally.
  i can draw a clear line between the previous twenty years of my life, and a few years ago.
  it's just weirdly amazing to able to have a small thing go wrong and just be like "ah dangit." rather than having a depressive spiral and mourning my own existence for the rest of the day.
  not that i don't sometimes have pessimistic thoughts or bad days, it's just not overwhelmingly defining of my every moment.
  at the very least, i'm eager to see a lot more research being done. if it is legitimate, and others can have the same change in life experience that i've had, then it's a damn tragedy it hasn't been studied more thoroughly ages ago.
  
  Yeah, its been an interesting transformation for me over the last few months, for sure. Psilocybin stopped being a party drug for me a while ago, actually. The drug isn't "showing me things" that I didn't already know, TBH. What I it is allowing me to do is parse through the extremely complex mind-fuck that I have been building for myself over the last 40 years.
  My depression is gone and my anxiety is fading. I stopped my SSRIs a few weeks ago and had the mildest withdrawal from them that I have ever had in my life. My sleeping habits need a fuck ton more work, but one problem at a time.
  Similar to Stamets and his story about stuttering, I am learning that I have much more control over my body than I previously realized, mood included.
  I don't want to go so far as say it is a miracle drug, but it is absolutely rebuilding parts of my brain that I was trying to extinguish with hardcore alcoholism. There is something to this.
  More controlled research please. If anyone needs a guinea pig for lab testing, sign me the fuck up! (I am trying to get in a study at UC Boulder this year so they can poke at me a bit.)
  
  I've never tried shrooms but I'd love to, not sure if I expect it to help at all with my adhd but at least the depression might improve, and I've heard it can make a person more empathetic, which sounds awesome
  
  I have had little improvement with my concentration and still lean heavily on my daily Adderall so I can be functional at life.
  To my limited understanding, most people with ADD/ADHD also have anxiety and depression. I mean, it makes sense. We tend to struggle with things that most other people find simple or second nature and that is extremely stressful. I believe that is the source of the anxiety, which can lead to depression after a while. Just my theory, anyway.
  If you do decide to try psychedelics, remember that you are just going for a small journey inside your own brain and it can be jarring as fuck the first couple of times. However, I personally welcome what others might consider a "bad trip". My personal view is that a "bad trip" is part of my mind that I need to confront and understand at an extremely personal level.
  With practice, I have learned to shut off negative emotions as easily as turning off a light switch. It's a very peculiar feeling, to say the least.
  And yes. Extreme empathy is one of the best feelings you can get and it is also something I am trying to carry with me into my daily life. It really is a powerful experience to feel connected with everything around you.
  At the end of the day, If you are in a comfortable environment and have some good music going, it is a very healthy thing to do.
  I could go on for hours, but alas, it is late.
  Take care!
  
  Thanks for the response! I'm falling asleep myself and don't have much coherent to say in response lol but I enjoyed reading what you had to say. It has me even more interested in trying shrooms.

46 comments