Still a couple deal breakers for me, though most stuff otherwise runs fine.
No HDR support. Sucks if you have a great monitor but can't use it.
No nvidia broadcast. Necessary for my mic+speaker setup, common alternative such as noisetorch are convenient, but don't even come close to echo filtering quality from the speakers. Yes, that's super subjective obviously.
Performance tends to be noticeably to only slightly worse on max settings with nvidia on highly specialized, very demanding games.
Some anti cheat tools struggle with compatibility modes.
We're getting there, but it's tough with nvidia not caring. :/