I try to speak respectfully to whoever I speak to and that includes using pronouns they want so getting it wrong is always unintentional. But I'll still always speak to any group of people as "you guys". I use that speaking to my 16 yo daughter and her girl friends. It's just not gendered speech, and I know some disagree but whatever
Context matters. Addressing a group full of mixed men and women? Guys is totally acceptable. Discussing how many men someone has had intercourse with? Guys means only men lol