Peaches - Trans Megathread from April 7th, 2025 to April 13th, 2025

Didn't have a chance to write up a detailed post, either on a fruit or the topic I was originally thinking about. I think they're neat and they taste good.

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523 comments

Hello gamers, I got my blood work back and don't really know what to make of it
T: ~90 ng/dL
E: ~65 pg/mL
Is this normal for 2.5 months on HRT? I was on 4mg estradiol a day for the first month and a half and then bumped up to 6mg, plus 100mg Spiro a day (unchanged throughout). I definitely missed doses here and there, but maybe only a handful throughout.
- E doesnt come in ng/dL, are you sure you are reading the levels correctly? It should be pg/mL or pmol/L.
  
  Oh yup I misread it's pg/mL
  
  okiii well general recommended levels are E2: 100-200 pg/mL (367-734 pmol/L) and T: < 50 ng/dL (1.7 nmol/L) so u pawbably neeeddd a bit higher dose. how are u taking the E?
  
  Oral tablet/pill. I'm interested in injections because I hear people often respond to that better and I already do weekly injections w/ semaglutide so what's another shot?
  
  Do you just swallow the pill? putting it under the tongue or letting it dissolve in your cheek gets more of it straight to the bloodstream.
  Also with the gel just put it right on the girldick, it's about three times as effective than anywhere else.
  i have no tricks for injections
  
  Shot tricks:
  For DIY you can often use 31g insulin needles because the liquid is thinner than the perscribed stuff and subq has comprable uptake rates to IM (to my knowledge at least)
  You can use use a vial for more than just a month, as long as its kept steril and the stopper is fine.
  If you kinda squeeze a squigly with your skin you can trap the estradiol in there after taking the needle out, if youre having issues with leakage.
  Thats all i got, and it aint medical advice lol
  
  now this is
  posting
  very nice
  
  subq and im have identical levels with all esters except EUn
  
  This has been my experience as well, except i havent tried eun
  
  Isn't my mouth gonna be all bitter if I just keep it in there instead of swallowing?
  
  with normal meds yeah, estrogen (in my exoerience) have a layer of something sweet so they taste like candy
- Not really surprising. There's a lot of variation from person to person it seems, so starting doses often are not enough, but serve to get an idea of what is needed.
- It's pretty low. Also make sure you take your blood test as close as possible to right before the next dose (of pills or of an injection). This is the trough level and it's what we base our adjustments on. If you took the blood at any other time it will seem that the level is high, but this will be useless for making any conclusions.
  If you are going to let the pill dissolve in your mouth, then spread it out over the course of a day. Don't put all your pills under your tongue/near your cheek all at once. If you need to split a pill in half to be able to take it throughout the day, then use a pillsplitter to make your life easier. It will take 30 mins to an hour to dissolve a full 2mg pill, anything left over in your mouth after that is filler material in the pill, just swallow it.
  
  Hmm the blood was taken around 2pm, and I take the pills at like 6:30am and 8:15pm. So my real levels might be even lower? Dang
  
  my PP doctors have me taking my levels mid way through the week, so i inject saturday and go in on wednesday for the blood draw; is there merit in going in on friday instead because I am getting checked again to see if monotherapy is working in a couple months.
  I don't really want to lie to them but i will if they are off about this!
  
  Sorry, just saw this. I am writing this with the assumption that you inject estradiol enanthate. If they're taking at the middle point between doses, that means they want your peak levels. If you take EEn every 7 days, then the variation between peak and trough could be from 20pg/ml to 50pg/ml depending on a lot of factors. In the ideal case, you want a minimum trough level of 200pg/ml, and then adjust up or down slightly depending on your mood and based on the level of feminization you experience. It's a trial and error process that might take a very long time, and can even change after years without apparent reason. I suggest you measure your trough level.
  
  fascinating. It's estradiol valerate. I'll have it done on a friday as was you are saying makes sense and they are letting me schedule it myself.
  appreciate the reply!
  
  estradiol valerate
  This has an even shorter half life so the variation will be higher than with EEn. Feel free to ask for help when you get your results or for any other reason. Good luck!

523 comments