Depends. For turn based, or slower strategy, or where you don't need too much info on screen, mobile works. If it's something fast paced (Command&Conquer) or with lots of stuff going on at the same time (SupCom) or with lots of micromanagement needed, mobile might feel awful. It's like only ever having a mouse with a working scroll wheel to play a game.
Did you tried UnCiv ? Feels like garbage to play to me. Maybe it is just too complete for my mobile game sessions... (And I don't really like civilisation turn based games anymore.)
Mindustry (factorio like) plays badly on mobile (everything is too small, touch is not precise need to zoom a lot but you don't see anything/can't build long belt that way). But now I want to play it on PC.
On the other hand, Feudal Tactics is really nice to play on mobile.